| U.S. Neurologists Agree On Protocols For Treatment Of Infantile Spasms |
| Researchers from across the U.S., as part of the Infantile Spasms Working Group (ISWG), established guidelines for the diagnosis and treatment of infantile spasms (IS). The goal of the ISWG is to improve patient outcomes by creating protocols that educate pediatricians on early diagnosis and treatment options... |
| Read More...(Source: Epilepsy News From Medical News Today - Sat, 04 Sep 2010 01:00:00 PDT) |
| Position Statements About The Post-Reproductive Health Of Women Published By EMAS |
| Elsevier has announced the publication of four important position statements from the European Menopause and Andropause Society (EMAS) in the journal Maturitas on common management problems in the post-reproductive health of women. The statements cover the management of the menopause in the context of obesity, epilepsy, endometriosis and premature ovarian failure... |
| Read More...(Source: Epilepsy News From Medical News Today - Sat, 04 Sep 2010 00:00:00 PDT) |
| GSK And Valeant Announce New U.S. FDA PDUFA Goal Date For Ezogabine |
| GlaxoSmithKline (NYSE: GSK) and Valeant Pharmaceuticals International (NYSE: VRX) announced the U.S. Food and Drug Administration (FDA) has extended the Prescription Drug User Fee Act (PDUFA) goal date for ezogabine to 30 November 2010. The original goal date was 30 August 2010... |
| Read More...(Source: Epilepsy News From Medical News Today - Wed, 01 Sep 2010 02:00:00 PDT) |
| Study Shows Brain Trauma Associated With Lifelong Conditions That Affect Quality Of Life And Mortality |
| Traumatic brain injury, currently considered a singular event by the insurance industry and many health care providers, is instead the beginning of an ongoing process that impacts multiple organ systems and may cause or accelerate other diseases and disorders that can reduce life expectancy, according to research from the University of Texas Medical Branch at Galveston... |
| Read More...(Source: Epilepsy News From Medical News Today - Mon, 30 Aug 2010 01:00:00 PDT) |
| High-Fat Diets Effectively Treat Absence Epilepsy |
| Two high-fat diets the classic ketogenic and a modified version of the Atkins can reduce and, in some cases, completely eliminate seizures in children with a common seizure disorder known as absence epilepsy, say researchers from Johns Hopkins Children's Center... |
| Read More...(Source: Epilepsy News From Medical News Today - Fri, 27 Aug 2010 00:00:00 PDT) |
| Gene Therapy To Treat Epilepsy A Step Closer |
| Current antiepileptic drugs (AEDs) have many side-effects, among others slowing down brain activity, which in turn reduces patients' ability to react. These side-effects could be eliminated if genes that counteract seizures could be introduced into the brain. Professor Merab Kokaia at Lund University in Sweden has obtained promising results in animal experiments... |
| Read More...(Source: Epilepsy News From Medical News Today - Thu, 26 Aug 2010 02:00:00 PDT) |
| Eisai Announces Positive Phase III Trial Results For Perampanel In Epilepsy |
| Eisai Inc. announced the results of a Phase III study for the investigational compound perampanel (E2007), a first-in-class, highly selective non-competitive AMPA-type glutamate receptor antagonist, discovered by Eisai and being developed for treatment of partial seizures in patients with epilepsy... |
| Read More...(Source: Epilepsy News From Medical News Today - Thu, 26 Aug 2010 01:00:00 PDT) |
| Cyberonics Announces Epilepsy Technology Agreements |
| Cyberonics, Inc. (Nasdaq: CYBX) announced that it has entered into additional agreements with NeuroVista Corporation in the field of EEG-based seizure detection to build on its position as the leader in medical devices for epilepsy... |
| Read More...(Source: Epilepsy News From Medical News Today - Wed, 25 Aug 2010 04:00:00 PDT) |
| Eisai Announces Positive Results Of Phase III Trial For Perampanel In Epilepsy |
| Eisai Co., Ltd. (Headquarters: Tokyo, President & CEO: Haruo Naito, "Eisai") announced that results of a Phase III study in epilepsy patients with refractory partial seizures demonstrate the clinical benefits of the novel investigational compound E2007 (generic name: perampanel)... |
| Read More...(Source: Epilepsy News From Medical News Today - Wed, 25 Aug 2010 04:00:00 PDT) |
| Epilepsy Organizations Award Grants For New Gene Therapy To Treat Epilepsy And Novel Surgical Intracranial EEG |
| The Epilepsy Therapy Project (ETP) and the Epilepsy Foundation (EF) announced the latest grant recipients of its New Therapy Grants Program, a unique joint venture of the non-profit epilepsy organizations, to advance promising epilepsy research in clinical development... |
| Read More...(Source: Epilepsy News From Medical News Today - Tue, 24 Aug 2010 02:00:00 PDT) |
| Link found between memory, nerve cell production in humans |
| Production of new nerve cells in the human brain is linked to learning and memory, according to a new study from the University of Florida. The research is the first to show such a link in humans. The findings, published online and in an upcoming print... |
| Read More...(Source: Epilepsy - 2010-08-31 07:15:35) |
| Brain operation quiets the storm of seizures for epileptics |
| Starting at age 3, Breanna Osborn had 40 to 60 epileptic seizures every day of her life. Some were quick — the blond girl that her family calls "Weeble" shook her hands, smiled and moaned. Other episodes were violent, causing Breanna to jerk her... |
| Read More...(Source: Epilepsy - 2010-07-24 19:08:00) |
| Women with Epilepsy |
| Generally, the female role in the family is to act as a caretaker. Dealing with Epilepsy, whether a woman is diagnosed or caring for someone who is, can be overwhelming. But you are not alone. If you need more advice or access to more resources, visit... |
| Read More...(Source: Epilepsy - 2010-07-20 10:12:29) |
| Veterans can have seizures decades after a head injury, study finds |
| Soldiers who suffered brain injuries can develop seizures decades — as long as 35 years — after the initial injury, researchers have found. A study published Tuesday in the journal Neurology found that among a group of 199 Vietnam veterans,... |
| Read More...(Source: Epilepsy - 2010-07-20 00:00:00) |
| Pot Of Gold Or Pipe Dream? |
| In about a dozen states, you can smoke a joint if you have cancer or HIV and meet certain conditions, like having a doctor's note. In California, you can light up if you have just about anything — headaches, anxiety, epilepsy — and a... |
| Read More...(Source: Epilepsy - 2010-06-17 00:00:00) |
| PASSINGS: Betty Ticho, Stuart Gavert, Peter Brunette, Sue Avery, Bill Dixon, John Bucalo |
| Betty Ticho Co-founder of L.A. County epilepsy group Betty Ticho, 89, a social worker who co-founded the Los Angeles County Epilepsy Society and served as its executive director for 30 years, died May 29 at Santa Monica Hospital of complications from... |
| Read More...(Source: Epilepsy - 2010-06-22 00:00:00) |
| Dog helps Aurora man battle high healthcare costs |
| DENVER - He was on the front lines of helping the sick and injured, and now he can't afford the care he badly needs. An Aurora man says he's the face of what's wrong with the healthcare system, and activists in the disabled community say his story is far... |
| Read More...(Source: Epilepsy - 2010-06-17 18:05:00) |
| Your Infant Is Having A Fever-induced Seizure - What Are The Two Common Mistakes Parents Make? Angela King Shows Us The Do's And Don'ts |
| Your infant or toddler is sick with a fever, when all of a sudden, they have a seizure. What would you do? "It's a scary situation for any parent," says Captain John Keizer with the Kent Fire Department. Febrile seizures occur in children ages six... |
| Read More...(Source: Epilepsy - 2010-06-02 00:00:00) |
| Man on long bike ride stops in Denver |
| DENVER - Going from Miami to Alaska is not a short trip. Especially on a bicycle. But one man is going the distance in the name of raising epilepsy awareness. Glenn Fenster stopped at FOX31 in Denver this week. He's been on the road for about 35 days.... |
| Read More...(Source: Epilepsy - 2010-05-11 08:49:00) |
| Metro Documentary Filmmakers Hope to Shed Light on Epilepsy |
| Epilepsy, though hardly a rare disease, still remains a mystery to many people. But a new documentary being produced by and featuring metro residents could help change all of that. "It is Epilepsy" was the brainchild of former Warrensburg resident... |
| Read More...(Source: Epilepsy - 2010-05-04 00:00:00) |
| Denver Tea Party rally draws hundreds |
| DENVER - Passion. Anger. Excitement. Those were just some of the emotions brewing at the Tea Party Express III rally at the Colorado State Capitol Wednesday. "It's very frustrating and it's frustrating to watch how some of this stuff has come down," said... |
| Read More...(Source: Epilepsy - 2010-03-31 21:26:00) |
| Popular anticonvulsant drugs raise suicide risks |
| Widely used anticonvulsant drugs, including Pfizer's Neurontin and Novartis' Trileptal, may increase the risk of suicide, attempted suicide and violent death in patients taking them for the first time, U.S. researchers said this week. Compared with... |
| Read More...(Source: Epilepsy - 2010-04-15 00:00:00) |
| Editorial Board |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Antiepileptic treatment in patients with epilepsy and other comorbidities |
| Abstract: Background: A high number of patients with epilepsy have comorbidities. The type of comorbidity is an important factor in deciding on the most suitable treatment, including that for acute epileptic seizures and chronic antiepileptic treatment. Evidence-based criteria should guide the selection of the appropriate antiepileptic drugs given specific comorbidities.Methods: We performed a comprehensive search of the scientific literature on epilepsy treatment in patients with the following comorbidities: heart disease, lung disease, liver disease, kidney disease, porphyria, organ transplantation, thyroid disease, metabolic disorder, infection, mental disability, psychiatric disorder, cognitive impairment, stroke, and brain tumour.Results: Most of the studies were case series and retrospective analyses. No randomised controlled trials specifically designed for this type of clinical situation were identified. The level of scientific evidence to guide clinical decisions is therefore low.Conclusions: In this review we make recommendations based on the best scientific evidence available for treating epilepsy in patients with other comorbidities, including the treatment of epileptic seizures in acute situations as well as chronic antiepileptic treatment. When no scientific evidence is available, our recommendations are based on pharmacokinetic criteria and tolerability of antiepileptic drugs, using accumulated experience and the consensus of the members of the Andalusian Epilepsy Society. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Senile myoclonic epilepsy: Delineation of a common condition associated with Alzheimer's disease in Down syndrome |
| Abstract: In Down syndrome (DS), epilepsy is frequent in all age classes and is recognized as a significant cause of additional handicap and morbidity. Longer life expectancy has led to the recognition of the high incidence of both Alzheimer's disease and seizures in elderly persons with DS. Neuropathological markers of AD are found in all DS brains and clinical symptoms of AD become apparent by the age of 60 years and above in over 50% of DS subjects. Following preliminary description of myoclonic seizures and/or myoclonic epilepsy in isolated cases or small series, we wish to report the diagnostic criteria, treatment and prognosis of a specific and recognizable form of epilepsy associated with AD in a larger group of middle-aged to elderly DS patients. This markedly under-recognized entity may indeed concern an already large and steadily increasing number of patients. We reviewed all medical records of patients with DS referred to our centers (Centre Saint Paul-Gastaut, Marseille; Epilepsy Unit, Montpellier University Hospital; Department of Neurology, Hospital General de Asturias, Oviedo) since 1995. DS had been diagnosed in all at birth, and all presented with the typical morphological changes associated with DS. We selected all cases (18) referred as adults with new onset of myoclonic jerks (MJ) and/or behavioral or cognitive deterioration (CD). |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery |
| Abstract: Purpose: Intracerebral delivery of anti-epileptic compounds represents a novel strategy for the treatment of refractory epilepsy. Adenosine is a possible candidate for local delivery based on its proven anti-epileptic effects. Neural stem cells constitute an ideal cell source for intracerebral transplantation and long-term drug delivery. In order to develop a cell-based system for the long-term delivery of adenosine, we isolated neural progenitor cells from adenosine kinase deficient mice (Adk−/−) and compared their differentiation potential and adenosine release properties with corresponding wild-type cells.Methods: Fetal neural progenitor cells were isolated from the brains of Adk−/− and C57BL/6 mice fetuses and expanded in vitro. Before and after neural differentiation, supernatants were collected and assayed for adenosine release using liquid chromatography–tandem mass spectrometry (LC–MS/MS).Results: Adk−/− cells secreted significantly more adenosine compared to wild-type cells at any time point of differentiation. Undifferentiated Adk−/− cells secreted 137±5ng adenosine per 105 cells during 24h in culture, compared to 11±1ng released from corresponding wild-type cells. Adenosine release was maintained after differentiation as differentiated Adk−/− cells continued to release significantly more adenosine per 24h (47±1ng per 105 cells) compared to wild-type cells (3±0.2ng per 105 cells).Conclusions: Fetal neural progenitor cells isolated from Adk−/− mice – but not those from C57BL/6 mice – release amounts of adenosine considered to be of therapeutic relevance. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Detection of epileptic spikes by magnetoencephalography and electroencephalography after sleep deprivation |
| Abstract: Introduction: In diagnosis of epilepsies electrophysiological findings play a key role. While spontaneous electroencephalography (EEG) and EEG with sleep deprivation (EEGsd) are widely evaluated and used, application of magnetoencephalography (MEG) in this field is primarily limited to presurgical assessment of focal epilepsies.Methods: In this study we retrospectively compared MEG (M/EEG) and EEGsd in 63 (55) patients with focal and generalized epilepsy with regard to occurrence of epileptic spikes.Results: MEG could record epileptic spikes in 38 patients (60%), while EEGsd recorded spikes in only 32 patients (51%). In a group of 55 patients simultaneous MEG/EEG (M/EEG) was able to record spikes in 38 patients (71%) compared to epileptic spikes in 28 patients (51%) recorded by EEGsd. In a subgroup of 17 MR-negative patients simultaneous M/EEG could record epileptic spikes in all patients, while EEGsd was successful in only 11 (64%) of them.Conclusion: In this study, MEG showed a tendency to record epileptic spikes in more patients than EEGsd. Furthermore, simultaneous M/EEG has been shown to be especially successful in detection of epileptic spikes in patients with MR-negative epilepsy. This might at least in parts be explained by neocortical predominance of MR-negative epilepsy. Thus, this study motivates prospective studies to evaluate the substitutability of EEGsd by MEG more extensively. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Long-term outcome and tolerability of the ketogenic diet in drug-resistant childhood epilepsy—The Austrian experience |
| Abstract: Purpose: To evaluate the long-term efficacy/tolerability of the ketogenic diet (KD) in paediatric drug-resistant epilepsies.Methods: Data from children who were treated between 1999 and 2008 and had continuous follow-up of at least 6 months after initiation of the KD were analysed retrospectively. Response was defined as ≥50% seizure reduction. Treatment effects on EEG, developmental outcome and the “outcome-predictive” value of various clinical factors were also assessed.Results: 50 children (22 boys; mean age 4.5 years±3.55) were included. Mean follow-up was 3.93±2.95. 50% of the patients were responders, 48% of them became seizure free. 50% were non-responders, 20% of them deteriorated. In responders, EEG background activity improved significantly (p=0.014) and a significantly lower rate of epileptic discharges (p=0.009) was seen after 6 months. In addition, neurological examination findings demonstrated significant developmental progress (p=0.038).Favourable treatment outcome was associated with a shorter disease duration (p=0.025) and generalised tonic clonic seizures (p=0.059). No further significant outcome predictors were detected. However, response was 44% in patients with infantile spasms, 62.5% in those with Dravet syndrome and 50% in Lennox-Gastaut-syndrome.Side effects occurred in 28%, but discontinuation of the KD was not required in any case. They most often observed with concomitant topiramate (p=0.001) and valproate (p=0.046).Conclusion: Despite the retrospective nature of the study and the inhomogeneous patient sample, we found good long-term effects of the KD on seizure frequency, EEG and neurological development. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Active seizures are associated with reduced adaptive functioning in children with epilepsy |
| Abstract: Children with epilepsy are at risk of suboptimal adaptive functioning. Research has not yet established how specific seizure and treatment variables may affect adaptive functioning, which would allow clinicians to better identify at-risk children. This study sought to determine the seizure and treatment variables predictive of adaptive functioning. Forty-six children with epilepsy participated in this study. Using multiple regression, active seizures (one or more seizures in the prior year) significantly predicted scores on the General Adaptive Composite of the Adaptive Behavior Assessment System-II. The active seizures variable uniquely explained 19% of the variance in adaptive functioning, with children with active seizures demonstrating significantly poorer adaptive functioning. The number of current AEDs, past AEDs, seizure types, age at seizure onset, and temporal lobectomy were not significant predictors. Post hoc analyses that divided the active seizures group according to seizure frequency in the prior month did not find significant differences in adaptive functioning. The results of this study suggest that children with seizures that are not fully controlled are at greater risk of suboptimal adaptive functioning. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Status epilepticus alters hippocampal PKAβ and PKAγ expression in mice |
| Abstract: Objectives: To investigate the localization and progressive changes of cyclic-AMP dependent protein kinase (cPKA) in the mouse hippocampus at acute stages during and after pilocarpine induced status epilepticus.Methods: Pilocarpine induced status epilepticus mice were sacrificed 30min, 2h or 1 day after the start of a ∼7h lasting status as assessed by video-electroencephalography. Brains were processed for quantitative immunohistochemistry of hippocampal cPKAβ and cPKAγ, and immunohistochemical co-localization of cPKAβ and cPKAγ with calbindin (CB), calretinin (CR), and parvalbumin (PV).Results: Based on anatomical and morphological assessment, cPKAβ was primarily expressed by principal cells and cPKAγ by interneurons. In CA1, cPKAβ co-localized with 76% of CB, 41% of CR, and 95% of PV-immunopositive cells, while cPKAγ co-localized with 50% of CB, 29% of CR, and 80% of PV-immunopositive cells. Upon induction of status epilepticus, cPKAβ expression was transiently reduced in CA1, whereas cPKAγ expression was sustainably reduced.Conclusion: cPKA may play an important role in neuronal hyperexcitability, death and epileptogenesis during and after pilocarpine induced status epilepticus. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Does a preference for fatty foods prior to commencing treatment with the ketogenic diet predict the efficacy of this diet? |
| Abstract: The ketogenic diet can be effective in children who suffer from drug-resistant epilepsy. However, it is still hard to predict how large an effect this diet will have for an individual child. Previous data suggests a high-fat food preference is more likely in those with epilepsy, as assessed by in-person forced-choice design. The aim of this study is to examine whether a partiality to fatty foods prior to commencing the ketogenic diet can be used as a predictive factor for the efficacy of this diet in children with drug-resistant epilepsy.Data from 43 children aged between 2 and 19 years was used in this retrospective, non-controlled, non-randomised, open study. All children had followed the ketogenic diet for a period of 3 months or more. Before commencing the diet, a food record was collected for each child to determine the percentage of daily energy-intake accounted for by fats. Parents of the participants completed a questionnaire to measure fat-preference in the pre-diet period and received a score to objectify the efficacy of the treatment.The raw scores on the food record and on the questionnaire were divided into subgroups. Subsequently Kendall's tau-b was calculated for the correlation between each combination of variables. A non-significant correlation was found for the relationship between the food record and the questionnaire (p=.939), the relationship between the food record and the efficacy of the treatment (p=.827) and the relationship between the questionnaire and the efficacy of the treatment (p=.539). This means treatment efficacy cannot be predicted by the child's food preference. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Association between structural abnormalities and fMRI response in the amygdala in patients with temporal lobe epilepsy |
| Abstract: Objective: The goal of this study was to investigate whether dysplastic amygdalae show an impaired response as revealed by functional MRI (fMRI).Methods: A fearful face fMRI paradigm using video sequences, as we have recently applied, was used in 25 patients with temporal lobe epilepsy (TLE): 24 had mesial TLE (14 right-, nine left-sided, one bilateral); one left lateral neocortical TLE. T1-, T2-weighted and fluid attenuated inversion recovery (FLAIR) MRI sequences were assessed for the detection and categorisation of structural amygdalar abnormalities according to size and MR signal intensity. Of the 25 patients, five patients had probable dysplastic amygdala (pDA): two right- and three left-sided.Results: A fearful face paradigm led to significant amygdalar activation in all but one patient (p |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Quality of life and treatment satisfaction in Spanish epilepsy patients on monotherapy with lamotrigine or valproic acid |
| Abstract: Background: Patients suffering from epilepsy have an impaired health related quality of life (HRQoL) because of seizures and treatment adverse events. Epilepsy affects differently both genders, due to hormonal influence in women. The aim of this study is to assess the impact on HRQoL and treatment satisfaction in epilepsy patients treated with stable doses of lamotrigine and valproic acid.Methods: Observational cohort prospective study was conducted in 18 Spanish neurology sites. Patients with clinically stable partial or generalized epilepsy, already receiving lamotrigine or valproic acid on monotherapy, were assessed in two visits: baseline and at 6 months. Socio-demographic and clinical variables were recorded at baseline; HRQoL (QOLIE-10) treatment satisfaction and women image self-perception were assessed at both visits. Impact on HRQoL was assessed in both treatment arms overall and in the women subgroup.Results: A total of 107 patients were evaluated; 53 (14 men, 39 women) on lamotrigine and 54 (27 men, 27 women) on valproic acid. Mean (SD) age was 30.4 (9.1) years and mean (SD) time since epilepsy diagnosis was 8 (8.1) years. Mean (SD) QOLIE-10 score at baseline was 73.9 (15.7) points (76.6 and 71.4 for lamotrigine and valproic, respectively). At follow up, patients reported better HRQoL on both lamotrigine (78.8 points) (p |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans |
| Abstract: The 1mm long Caenorhabditis elegans is one of the prime research tools to study different human neurodegenerative diseases. We have considered the case in which increase in the surrounding temperature of this multicellular model leads to abnormal bursts of neuronal cells that can be linked to seizure or convulsion. The induction of such seizure/convulsion mechanism was done by gradually increasing the temperature with 1× buffer (100mM NaCl, 50mM MgCl2) in adult C. elegans. In the present experiment it is demonstrated that Baccoside A can significantly reduce the seizure/convulsion in C. elegans at higher temperatures (26–28±1°C). Furthermore, in T-type Ca2+ channel cca-1 mutant worms, no convulsion was recorded. Our experimental results suggest that plant molecules from Bacopa monnieri may be useful in suppressing the seizure/convulsion in worms. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Milder phenotype with SCN1A truncation mutation other than SMEI |
| Abstract: Till now truncation mutations of voltage-gated sodium channel alpha subunit type I (SCN1A) gene were mostly found in severe myoclonic epilepsy of infancy (SMEI) patients. In this research we first identified two novel de novo truncation mutations (S662X and M145fx148) in two patients whose phenotypes were quite milder compared with SMEI patients. One patient was diagnosed as generalized epilepsy with febrile seizures plus (GEFS+); the other had focal seizures. Both patients had good response to anti-epileptic therapy (valproate or the combination of valproate and topiramate). Our findings extended the utility of the SCN1A gene testing and further confirmed the complex relationship between genotype and phenotype of SCN1A mutations. Further work is needed to optimize the protocol for specific genetic testing in children with epilepsy. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Non-paraneoplastic limbic encephalitis characterized by mesio-temporal seizures and extratemporal lesions: A case report |
| Abstract: Limbic encephalitis (LE) can be either paraneoplastic or a non-paraneoplastic autoimmune disorder. Magnetic resonance imaging (MRI) of the brain on T2-weighted fluid-attenuated inversion recovery (FLAIR) classically shows hyperintensities of the temporal structures, but multifocal involvement of extratemporal cortex has also been described in paraneoplastic LE. Here we describe a 27-year-old woman whose idiopathic autoimmune (glutamic acid decarboxylase-antibody positive) LE debuted with multiple daily mesio-temporal seizures, amnesia and multifocal extratemporal cortical MRI abnormalities. Mesio-temporal MRI signal increase was found after 20 days. This case report highlights that early diagnosis of non-paraneoplastic LE may be considered in patients with multiple daily mesio-temporal seizures and amnesia even in the absence of early typical MRI abnormalities. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Absence epilepsy and periventricular nodular heterotopia |
| Abstract: We report a case of a girl who presented with typical absence seizures at age of 4.5 years. EEG showed absence seizures of sudden onset with 3Hz spike-and-waves that also correlated with the clinical absences. The seizure semiology included subtle deviation of the eyes which prompted MRI investigation of the brain. This showed a periventricular nodular heterotopia in the mid to anterior horn of the right lateral ventricle. Although possibly coincidental, periventricular heterotopia are considered to be epileptogenic and this association has been reported once before. Migration disorders, such as in the periventricular heterotopia of our patient, may influence the formation and excitability of the striato–thalamo–cortical network involved in the generation of 3Hz spike-waves. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| Peri-ictal heart rates depend on seizure-type |
| We have read with great interest the recent article of Nilsen and colleagues. The authors have investigated heart rates at different peri-ictal time points in non-generalized seizures of patients with partial epilepsy and compared those to peri-ictal heart rates in patients who had had secondarily generalized tonic–clonic seizures (SGTC). Their major finding was that patients with SGTC had higher pre-ictal heart rates. |
| Read More...(Source: Seizure: European Journal of Epilepsy) |
| The Michael Prize 2011 |
| Read More...(Source: Seizure: European Journal of Epilepsy) |